Pseudarthroses

Successful treatment of nonunions with orthogold280

A pseudarthrosis is defined as a non healing fracture from which a false joint develops. It is manifested if healing of a fracture has not been achieved within six months after fracture development. Nonunions occur in 5% to 10% of all fractur patients. They are usually very painful and limit the mobility of concerned patients.
The current standard of care for the treatment of pseudarthrosis comprises debridement of the pseudarthrotic tissue, cleaning of the fragments edges, insertion of autologous spongiosa and stabilization with osteosynthesis material. However, these surgical procedurces are very costly as well as time consuming, are associated with a high complication rate and last but not least extremly traumatic for the patient. Consequently there is a high interest in a non-invasive, effective and efficient treatment option for pseudarthrosis. MTS’ Spark WaveTM therapy with orhtogold280 represents such a therapy method.

How do Spark WavesTM work in the treatment of nonunions?

Spark WavesTM have been documented to have various effects on bone tissue. Generally speaking, they stimulate the re-iniation of stagnant healing processes in sub-acute and chronic conditions and appear to initiate a more rapid andeffective healing phase in acute conditions. Spark WavesTM activate the natural healing powers of the tissue and induce amongst others the following biological reactions on cellular level:

  • development of angiogenetic growth facotrs such as VEGF, eNOS etc.
  • regeneration of blood vessels and consequently improved blood supply of affected areas
  • decrease of inflammatory processes
  • stimulation of osteoclasts and fibroblasts for rebuilding of injured tissue as well as
  • migration of stem cells.

The combination of all factors stimulates the healing process and finally leads to complete healing of bone fractures.

How is the treatment of pseudarthrosis conducted with orthogold280?

Depending on the region to be treated, Spark WaveTM therapy is adminidstered under general, regional or local anaesthesia. The extremtity to be treated is placed in such a way that it may be optimally reached with orthogold280. During the therapy process, the fracture is localised via imaging system, ultrasound gel is applied and the therapy head moved across the affected area whilst releasing the Spark WaveTM pulses. The quantity and intensity of the Spark WaveTM pulses chosen depends on the indication. Following Spark WaveTM treatment the pseudarthrosis is immobilzed with a plaster cast or plastic splint until fracture healing is completed.

What is the healing success rate for the treatment of nonunions with orthogold280?

The non-invaisve shock wave treatment with orthogold280 has a proven healing rate of over 80% and hence represents an effective and efficient alternative to surgery.

Treatment duration and number of treatments required with orthogold280

In general, one single treatment with orthogold280 is necessary for the successful therapy of nonunions. Very rarely a second or third treatment becomes neccessary three repsectively six months after the first treatment.